History of GW501516

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GW-50516 is a PPAR receptor agonist invented by the American pharmaceutical company Ligand and the British company Glaxo Smith Kline in the 1990s. GW-501516 is a unique drug commonly marketed as Cardarine, usually sold as SARMs but not SARMs.
GW-501516 was originally used to treat obesity, diabetes, dyslipidemia and cardiovascular diseases. Those who undergo blood tests during the use of GW-501516 will find a significant increase in their cholesterol levels.
With the continuous development of research, bodybuilders quickly fell in love with GW 501516, calling it the "ultimate endurance enhancing supplement" and "fatty acid oxidant".
The function of GW-501516
Although many people consider cardarine (GW 501516) to be SARM, it is technically a PPAR delta agonist (peroxisome proliferator activated receptor).
GW 501516 activates AMP activated protein kinases to burn fat through complex regulatory mechanisms, increase the ability of skeletal muscle to uptake glucose, and enhance the transcriptional characteristics of muscle genes, especially those involved in preferential lipid utilization. Raising the body's metabolism to burn fat instead of muscle or carbohydrates may effectively reduce fat in clinical applications for obese patients without experiencing muscle breakdown metabolism or hypoglycemic effects.
GW 501516 also increases muscle mass. In experimental studies, mice fed a high-fat diet significantly improved glucose tolerance while reducing fat mass, indicating that GW 501516 is effective in preventing obesity.
For athletes preparing for competitions, GW501516 is a popular product that stands out for its ability to increase muscle endurance. It is not easily fatigued and trains harder. GW501516 significantly improves cardiovascular endurance and can eliminate the side effects of steroids, such as the impact of tranbolone on cardiovascular function and difficulty breathing. GW501516 can eliminate these side effects and increase HDL (good) cholesterol, reduce triglycerides, and decrease LDL (bad cholesterol).
GW501516 is also very helpful for weight loss. It can be added for a longer period of time with aerobic therapy. It does not have many metabolic effects of fat reducing drugs, which indicates that it will not cause muscle loss during weight loss. GW501516 improves food utilization, increases glucose intake levels, and reduces body fat storage.
The two most obvious advantages of it are increased aerobic endurance and fat breakdown ability, weight loss without losing meat, and elimination of some side effects.