Letrozole is an oral aromatase inhibitor, it is not an steroids, It is used for the adjuvant treatment of hormone sensitive breast cancer. It can against excess estrogen in body building. Letrozole does not reduce production of mineralo and glucocorticoids. On the contrary, its anti estrogen effects mainly interfere with estrogen receptors, rather than inhibit estrogen production. Letrozole anti estrogen is the first choice for athletes and bodybuilders use steroid cycle to reduce the swelling due to water retention, prevent breast development of breast tissue, . Dose of more than 2.5 mg / day may temporarily inhibit sexual impulse. Long term use of 5mg / day may lead to kidney problems.
Letrozole also suggests that bone healing may be delayed in adolescents. This may be due to the effect of growth hormone, so letrozole is used for the treatment of short stature in adolescents and children.