Letrozole is an oral aromatase inhibitor, it is not an steroids, It is used for the adjuvant treatment of hormone sensitive breast cancer. It can against excess estrogen in body building. Letrozole does not reduce production of mineralo and glucocorticoids. On the contrary, its anti estrogen effects mainly interfere with estrogen receptors, rather than inhibit estrogen production. Letrozole anti estrogen is the first choice for athletes and bodybuilders use steroid cycle to reduce the swelling due to water retention, prevent breast development of breast tissue, . Dose of more than 2.5 mg / day may temporarily inhibit sexual impulse. Long term use of 5mg / day may lead to kidney problems.
Letrozole also suggests that bone healing may be delayed in adolescents. This may be due to the effect of growth hormone, so letrozole is used for the treatment of short stature in adolescents and children.
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Taking 2.5 mg orally 1 times a day. Sex, age, liver and kidney function are not related to letrozole. Therefore, elderly patients and people with impaired liver and renal function do not need to adjust the dose. Daily oral letrozole 2.5mg, and drug side effects rate was 33%, the adverse effects to letrozole is mild or moderate, with nausea (2% ~ 9%), headache (0% ~ 7%), pain (4% ~ 10%), hot flashes (0% ~ 9%) and weight (from 2% to 8%) as the main performance.
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Letrozole can effectively inhibit the transformation of androgen to estrogen, and the activity of letrozole is 150~250 times stronger than that of the first generation aromatase inhibitor. Due to its high selectivity, no effect of glucocorticoid, mineralocorticoid and thyroid function, the use of large dose of corticosteroid substances secretion had no inhibitory effect, so it has a higher inhibitory effect of estrogen. Preclinical studies have shown that letrozole has no potential toxicity to all systems and target organs of the whole body, and has the characteristics of good tolerance and strong pharmacological activity. Letrozole is Widely used by bodybuliders in Australia and United States.
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