Proviron Mesterolone

Proviron(Mesterolone) is one of the oldest anabolic steroids on the market. Developed by Schering plough in 1934. TProviron(Mesterolone) is a kind of androgen which is assimilated by dihydrotestosterone (DHT) derived protein. It is one of the few oral steroids that does not belong to the 17aa group. The total bioavailability was much lower than that of all C17 AA oral steroids.

History:
Schering developed Proviron(Mesterolone) in 1934, the first drug to be used in clinical to treat "hormone related diseases" because it is an effective androgen. Therefore, Proviron(Mesterolone) will be developed at about the same time as methyltestosterone (1935) and testosterone propionate (1937), both of which are very ancient agents. Proviron(Mesterolone) has a long history of clinical efficacy and safety, and is still widely used in clinical practice. It is used to treat the decline of physical and mental ability caused by age and subnormal androgen level, low sexual desire, hypogonadism and infertility caused by insufficient androgen level (Proviron(Mesterolone) can improve the quality and quantity of sperm).

Pharmacological action:
Proviron(Mesterolone) is an effective protein assimilation hormone. The assimilation was similar to that of methyltestosterone, but the activity of androgen was only 1 / 4 of that of methyltestosterone. It can promote the synthesis of protein, inhibit the heterogenesis of protein, maintain the balance of positive nitrogen, promote appetite, increase muscle and weight. Promote the deposition of calcium and phosphorus in the tissue, promote the formation of bone cell stroma, accelerate the calcification and bone growth. Promote tissue regeneration and granulation, accelerate the repair of trauma and ulcer. Reduce cholesterol and improve lipid metabolism. It is mainly used for negative nitrogen balance caused by chronic consumptive diseases, osteoporosis, severe infection and burn, etc., to promote the growth of premature and immature infants.
The inhibition of gonadotropin was very small in the normal treatment dose,. Lack of gonadotropin inhibition, Androgen can stimulate spermatogenesis directly, and also affect sperm transport and maturation by affecting epididymis, tubular structure and seminal vesicle. Proviron(Mesterolone) seems to have a unique positive effect on some men's fertility, because its potential stimulating effect on sperm quantity and quality will not be offset by gonadotropin inhibition.

Side effect
Proviron(Mesterolone) does not aromatize,. When this steroid is used, there is no need for antiestrogen
There are side effects of Proviron(Mesterolone) at higher doses. This can include oily skin, acne and episodes of body / facial hair growth. It can also aggravate male type hair loss. Women have also been warned of the potential male impact. These may include deepening of sound, irregular menstruation, changes in skin texture, facial hair growth, and clitoral enlargement.
No hepatotoxicity. It may have harmful effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol and increase LDL (bad) cholesterol, which may translate HDL in a direction that is conducive to a greater risk of atherosclerosis.